Nitrative stress activates JNK and decreases retrograde transport of brain‐derived neurotrophic factor in basal forebrain cholinergic neurons
This suggests that JNK activation by peroxynitrite may be a mechanism by which nitrative stress reduces BDNF transport in BFCNs. This study reveals that age-related nitrative stress may contribute to BDNF transport deficits, leading to BFCN degeneration and cognitive decline in AD.
Authors
- Erika Kropf (ORCID: https://orcid.org/0009-0000-8594-2678)
- Margaret Fahnestock (ORCID: https://orcid.org/0000-0002-6815-0529)
- Sama Jaberi
- Jessica Fisher
Institutions
- McMaster University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104239
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00