Impact of Systemic Arterial Hypertension on Astrocytic Morphology and Function in Acute and Organotypic Hippocampal Slices
The findings highlight SHR-specific astrocytic morphological changes in acute slices, coupled with reduced astrocyte numbers and impaired glutamate uptake in organotypic cultures from both WKY and SHR rats. These alterations may contribute to the cognitive decline associated with SAH, underscoring the need for further research to elucidate the role of astrocytic dysfunction in SAH and its potential link to Alzheimer's disease.
Authors
- Felippo Bifi (ORCID: https://orcid.org/0000-0002-8921-6638)
- Débora Guerini de Souza (ORCID: https://orcid.org/0000-0003-2982-4989)
- Francieli Rohden (ORCID: https://orcid.org/0000-0002-9232-7371)
- Léo Anderson Meira Martins (ORCID: https://orcid.org/0000-0003-0878-0489)
- Diogo O. Souza
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto do Cérebro (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104937
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00