Novel sex‐specific candidate loci associated with Alzheimer disease identified through sex‐aware multi‐ancestry genome‐wide meta‐analysis
We identified sex-specific AD associations at loci with AD-relevant genes including STXBP6 (involved in AD relevant processes such as endolysosomal transport and synaptic transmission), NPAS3 (neurogenesis), COL4A2 (cerebral vasculature), ITPKA (learning/memory processes), PAQR3 (cholesterol homeostatis and neuronal function), and MORC1 (recently associated in a UK Biobank exome-wide sequencing study of dementia (Zhang et al. Alz & Dementia 2024). Understanding the nature of these associations could help explain sex differences in risk and progression for AD.
Authors
- Nicholas R. Ray
- Omar Garcia Rodriguez
- R. Mayeux
- Nicholas A. Kushch
- Sven‐Thorsten Dietrich
- Sterling C. Johnson
- Bush Wh
- Adam C Naj
- Li‐San Wang
- Susan H. Slifer
- Juan Young
- Giuseppe Tosto
- Margaret Pericak‐Vance
- Lindsay A. Farrer
- Alzheimer's Disease Sequencing Project (ADSP)
- Amanda Kuzma
- Kara L Hamilton‐Nelson
- Otto Valladares
- Jonathan L Haines
- Laura B Cantwell
- Logan Dumitrescu
- Christiane Reitz
- Ryan Dacey
- Brian W Kunkle
- Lily Wang
- Lissette Gomez
Institutions
- Boston University (US)
- NewYork–Presbyterian Hospital (US)
- University of Miami (US)
- Presbyterian Hospital (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106407
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00