Cannabigerol reverses mechanical allodynia through α <sub>2A</sub> ‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy
CBG reverses mechanical allodynia in CIPN by reducing presynaptic neurotransmission at VPL-to-S1HL synapses through the activation of α<sub>2A</sub>-adrenoceptors. These findings identify a thalamocortical circuit mechanism and a cannabinoid-sensitive target for neuropathic pain treatment.
Authors
- Nicholas Graziane
- Nathan M. Morris (ORCID: https://orcid.org/0000-0001-9988-9951)
- Quinn Wade (ORCID: https://orcid.org/0000-0002-9328-8722)
- Mariya Starostina
- Diana E. Sepúlveda
- Jennifer E. Lausch (ORCID: https://orcid.org/0009-0004-1891-7391)
- Christopher Brandl
- Alonso Cortez‐Resendiz
Institutions
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1111/bph.70281
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00