i <i>Neuron‐GEM</i> : Identifying Metabolic Alterations in Neuronal Subtypes Associated with Alzheimer's Disease Pathophysiology
We present the first manually curated metabolic reconstruction of human neurons, named iNeuron-GEM. This metabolic reconstruction is useful for integrating multi-omics data and predicting metabolic changes in neuronal subtypes in AD. The findings from integrated iNeuron-GEM analyses enable the identification of metabolic signatures and druggable targets in AD.
Authors
- Aaron B. Bowman
- Anke M. Tukker (ORCID: https://orcid.org/0000-0001-8973-4809)
- Hyunjin Kim (ORCID: https://orcid.org/0000-0003-1674-623X)
- Priyanka Baloni (ORCID: https://orcid.org/0000-0002-3382-4941)
- Boyu Jiang
Institutions
- Purdue University West Lafayette (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105320
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00