Nicotinamide ameliorates lipopolysaccharide-induced impairment of trophoblastic spheroid outgrowth in an <i>in vitro</i> implantation model
Our study confirmed that LPS-induced endometrial infection may inhibit embryo implantation. NAM treatment ameliorated the detrimental effects of LPS by modulating the expression of inflammatory cytokines and adhesion molecules. Further studies are needed to explore the potential use of NAM as an effective additive to improve embryo implantation rates in human in vitro fertilization-embryo transfer programs.
Authors
- Inyoung Kang
- W. L. Lee (ORCID: https://orcid.org/0000-0002-1457-7631)
- Jaewang Lee (ORCID: https://orcid.org/0000-0001-6801-7149)
- Wontae Kim
- Jin Hyun Jun
Institutions
- Eulji University (KR)
- CrystalGenomics (South Korea) (KR)
Publication Details
- Journal
- Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.5653/cerm.2024.07472
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Education, Science and Technology