Comparing Macro‐ and Micro‐structural Predictors of Subsequent Cognitive Impairment in the BLSA
The observed findings emphasize the utility of selected DTI and cortical thickness measures as sensitive markers of early changes in brain integrity. Further, we found sex-specific patterns in trajectories associated with cognitive status, with SI females showing more pronounced macrostructural brain changes in cortical regions and SI males exhibiting more significant changes in WM microstructural integrity. Our study highlights the importance of sex-stratified analyses in identifying early brain changes that predict later cognitive impairment.
Authors
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Sridhar Kandala (ORCID: https://orcid.org/0000-0002-6222-0872)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Tugce Duran
- Guray Erus
- Bennett A. Landman
- Susan M. Resnick
- Yang An
Institutions
- National Institutes of Health (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100392
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00