Locomotor and anxiety symptoms in the late‐onset Alzheimer's disease LOAD2 mouse model with normal age‐related cognitive decline
LOAD2 mice exhibit early locomotor deficits and heightened anxiety, which are commonly associated with AD. However, both models show similar age-related declines in exploratory behaviour and recognition memory. Thus, more extensive testing and/or environmental challenges will be needed to detect overt cognitive deficits in LOAD2 mice.
Authors
- Aram Abbasian
- Ashish Kadia
- John Georgiou (ORCID: https://orcid.org/0000-0003-4503-6384)
- Shinwon Kang
- Junhui Wang (ORCID: https://orcid.org/0000-0002-9165-5664)
- Graham L Collingridge
Institutions
- University of Toronto (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Occupational Cancer Research Centre (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105188
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00