Diabetes mellitus‐induced differential cerebellar volume reduction across Alzheimer's disease trajectory

DM influences cerebellar volume differently across the AD spectrum. Anterior lobe atrophy in normal cognition suggests early cerebellar vulnerability to DM, while posterior lobe atrophy in amyloid-positive MCI indicates accelerated degeneration in advanced amyloid pathology. The absence of significant changes in preclinical AD may reflect compensatory mechanisms. These findings highlight the complex interaction between DM and AD, with DM potentially exacerbating cerebellar degeneration in later disease stages.