Traditional vs. Double‐round Genotype Imputation in multi‐ethnic Cohorts

Our findings demonstrate that multiple rounds of imputation generally outperform the traditional single one in terms of accuracy, particularly for rare and ultra-rare variants. This improvement is confirmed in groups that have shown higher error rates after traditional imputation, such as individuals with predominant African ancestry (Sariya et al. 2019). These results highlight a valuable and easy approach for enhancing the quality of imputed data across populations, which could lead to more robust genetic association studies.