Excess prenatal folic acid supplementation alters cortical DNA methylation and gene expression networks
These molecular alterations conceivably present risks to brain development and provide functional congruencies with disruptions in neuronal connectivity maps that we have described in previous work, underscoring the potential for excess prenatal folic acid exposure to disrupt developing metabolic and neurological pathways.
Authors
- Viktoria Haghani (ORCID: https://orcid.org/0000-0002-3700-4027)
- Noemi Cannizzaro (ORCID: https://orcid.org/0009-0008-0071-6291)
- Simak Ali (ORCID: https://orcid.org/0000-0002-1320-0816)
- Janine M. LaSalle (ORCID: https://orcid.org/0000-0002-3480-2031)
- Konstantinos S. Zarbalis
- Ralph Green
Institutions
- Mansoura University (EG)
- Shriners Hospitals for Children - Northern California (US)
- University of California Davis Medical Center (US)
- UC Davis Children's Hospital (US)
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-12-24
- DOI
- https://doi.org/10.3389/fnut.2025.1699376
- Citations
- 1
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Shriners Hospitals for Children
- University of California, Davis