Assessing progesterone receptor modulation in glioblastoma: from <i>in vitro</i> and animal model to a human pilot protocol
Our research highlights the critical role PR in GB progression using <i>in vitro</i> and <i>in vivo</i> models. MF, a PR modulator, effectively reduced cell viability and sphere formation in cellular assays and significantly decreased tumor volume in an <i>in vivo</i> study. The pilot trial demonstrated the pharmacological safety of using MF as an adjuvant in GB treatment. Patients treated with MF showed a significant increase in survival, with an 80% survival rate at 1 year compared to 0% in those who were treated with the standard treatment.
Authors
- Silvia Anahi Valdés-Rives (ORCID: https://orcid.org/0000-0002-2104-4884)
- Denisse Arcos-Montoya (ORCID: https://orcid.org/0000-0002-6509-7662)
- Ignacio Camacho‐Arroyo (ORCID: https://orcid.org/0000-0003-2978-1253)
- Alejandro Ordaz-Ramos
- Talía Wegman-Ostrosky (ORCID: https://orcid.org/0000-0002-3207-6697)
- A. Navarrete (ORCID: https://orcid.org/0000-0002-5087-7594)
- Orwa Aboud
- Joaquín Manjarrez-Marmolejo (ORCID: https://orcid.org/0000-0001-6421-9624)
- Néstor Fabián Díaz
- Aliesha González-Arenas
- Marisol De La Fuente-Granada
- Patricia García-López
- Carlos Fabricio Guadarrama-Rangel
- Claudia Bello-Alvarez
- Bernardo Cacho-Díaz
- Daniela Ávila-González
- David F. Cantú-de-León
Institutions
- Instituto Nacional de Perinatología (MX)
- Instituto de Neurologia Y Neurocirugia (CU)
- Instituto Nacional de Cancerología (CO)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Instituto Nacional de Cancerología (MX)
- University of California, Davis (US)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Cancer Biology & Therapy
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1080/15384047.2025.2603095
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63