Predicting Limbic‐predominant Age‐related TDP‐43 Encephalopathy (LATE) based on In‐vivo MRI Features
This study developed MARBLE, a novel, automated, in-vivo marker of LATE-NC based on MRI features. MARBLE was trained on ex-vivo MRI and pathology data from a large number of community-based older adults and showed decent performance in-vivo (AUC=0.76). While further validation is needed in independent cohorts, MARBLE has the potential to significantly contribute towards in-vivo diagnosis, monitoring, prevention, and treatment of LATE-NC.
Authors
- Abdur Raquib Ridwan (ORCID: https://orcid.org/0000-0002-6600-7059)
- Mahir Tazwar (ORCID: https://orcid.org/0000-0002-6270-8798)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Arnold M Evia (ORCID: https://orcid.org/0000-0003-2262-890X)
- Julie A Schneider
- David A. A. Bennett
Institutions
- Rush University Medical Center (US)
- Illinois Institute of Technology (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_096121
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00