HHV-6–induced hydrocephalus with ventricular septa formation in an immunocompetent adult: illustrative case

Previous studies have linked HHV-6 to inflammatory states, occurring predominantly among children and immunocompromised adults, that manifest primarily as meningitis and encephalitis. This case highlights the fact that HHV-6 can cause life-threatening ventriculitis and hydrocephalus in immunocompetent adults. Pathophysiological mechanisms of virus-induced neuroinflammation yielding intraventricular septation formation are reviewed. https://thejns.org/doi/10.3171/CASE25273.