Zinc Protoporphyrin Functions as a Ferroptosis Inducer to Activate Heme-BACH Axis and Potently Suppress IDH1-Mutant Gliomas
We discover that IDH1 mutation induces ferroptosis by activating the heme-BACH axis. ZnPP, previously believed to function exclusively as a heme oxygenase-1 inhibitor, can competitively bind to BACH to exacerbate ferroptosis and potently suppress IDH1-mutant gliomas. This study reveals a novel metabolic mechanism for inducing ferroptosis and provides a potential therapeutic target for IDH-mutant gliomas. Paraffin-embedded human glioma samples were collected from Xijing Hospital, the First Affiliated Hospital of the Fourth Military Medical University (China) (project number: KY20233192-1). <i>Antioxid. Redox Signal.</i> 44, 145-163.
Authors
- F L Zhang
- Xing Gao (ORCID: https://orcid.org/0000-0002-7410-4051)
- Huangtao Chen (ORCID: https://orcid.org/0000-0002-2073-965X)
- Ruolin Wu
- Ping Hu (ORCID: https://orcid.org/0000-0002-0629-6274)
- Y. Yang
- Ruili Han
- Yu Gu (ORCID: https://orcid.org/0000-0002-5683-8078)
- Yating Nie
- Jing Ye
- Risheng Yang
- Yingmei Wang (ORCID: https://orcid.org/0000-0002-7647-331X)
- Yu Zhao
- Liying Zhang
- Zengshan Li
- Xiangmei Cao
- Jing Li
- Lijun Zhang
- Zhe Wang
- Yuan Yuan
Institutions
- Ningxia Medical University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Tang Du Hospital (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1177/15230864251394709
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52