No causal link between estradiol and Alzheimer's disease in females: a Mendelian randomization study
The results do not support a causal link of estradiol-related factors and AD risk in females as well as males. Future studies should assess other influencing factors, as well as implement sex-specific, causal frameworks to examine potential time-varying effects of hormonal fluctuations and periods of increased susceptibility to sex steroids such as the perimenopausal period.
Authors
- Cláudia Barth (ORCID: https://orcid.org/0000-0001-6544-0945)
Institutions
- Diakonhjemmet Hospital (NO)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101658
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00