Associations of ex‐vivo cellular circadian period with aging, tau, neurodegeneration, inflammation and clinical progression in older adults with cognitive impairment: Findings from BICWALZS cohort
Cellular circadian metrics, particularly period deviation, reflect aging-related neurodegenerative changes and cognitive impairments, while longer periods are linked to AD-specific pathology and faster clinical progression. These findings highlight their potential as biomarkers for AD and aging-related neurodegeneration, warranting further investigation.
Authors
- Hyun Woong Roh (ORCID: https://orcid.org/0000-0002-1333-358X)
- Chang Hyung Hong (ORCID: https://orcid.org/0000-0003-3258-7611)
- Sang Joon Son (ORCID: https://orcid.org/0000-0001-7434-7996)
- You Jin Nam (ORCID: https://orcid.org/0000-0002-6603-5586)
- Sunwoo Yoon
- Homin Song
- Eun Young Kim
- Sunhwa Hong
Institutions
- Ajou University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100114
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00