Herpes Simplex Virus type 1 DNA associated with brain region specific Tau levels measured by PET imaging
Our findings suggest that the effect of HSV-1 infection is complex and potentially protective against tau buildup in many brain regions. Conversely, tau may have a protective effect against HSV-1. These findings highlight the need for further research to elucidate the mechanisms underlying the relationship between HSV-1 and tau and their potential implications for neurodegenerative processes.
Authors
- Congcong Zhu (ORCID: https://orcid.org/0000-0002-0143-7453)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Marlene Tejeda
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- John J. Farrell (ORCID: https://orcid.org/0000-0001-6502-1572)
- Lee M. Wetzler (ORCID: https://orcid.org/0000-0002-6596-2986)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Gerald D. Schellenberg
- Li‐San Wang
- Caitlin Newman
- Richard Sherva
- Jonathan L Haines
- Margaret Pericak‐Vance
Institutions
- Boston University (US)
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106731
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00