Membrane vesicles from oral pathobiont <i>Porphyromonas gingivalis</i> and oral commensal <i>Neisseria oralis</i> both induce Tau phosphorylation but different murine brain responses
BMVs from both N. oralis and P. gingivalis entered the brain from the bloodstream but caused different host responses. Upon cessation of BMV injection, the BMVs were naturally removed from the brain over time, suggesting that treatment of the source of the BMVs, namely periodontitis, would reduce exposure to brain pathology causing agents.
Authors
- Giuseppe D. Ciccotosto (ORCID: https://orcid.org/0000-0003-2512-1047)
- Catherine A. Butler (ORCID: https://orcid.org/0000-0001-6371-3954)
- Stuart G. Dashper (ORCID: https://orcid.org/0000-0003-0106-8691)
- Elly Bijlsma
Institutions
- The University of Melbourne (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104710
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47