Assessment of Association of Tau PET Spatial Patterns with Cognitive Domains in Participants with Early Alzheimer's Disease in the Phase 2 Auτonomy Trial

In participants with intermediate tau and early AD, randomized in the Auτonomy trial, we map using a spatially unbiased analysis of tau PET, which cognitive domains are relatively most impacted by tau pathology across the brain. The ensuing maps reflect established brain functional organization. These findings demonstrate close association between presence/location of tangles and cognitive profile.