Is FIB-4 the right tool for screening for liver fibrosis?
The FIB-4 index showed poor agreement with VCTE and low sensitivity, making it an unreliable standalone diagnostic tool for liver fibrosis in people with MASLD in both primary and secondary care. Alternative non-invasive tests or improved cut-off values are needed for accurate fibrosis detection in clinical practice.
Authors
- Ger H. Koek (ORCID: https://orcid.org/0000-0002-7863-392X)
- Yves Kockaerts
- IN Akpinar
- Jean Muris (ORCID: https://orcid.org/0000-0002-8780-476X)
- Geert Robaeys (ORCID: https://orcid.org/0000-0003-3930-5664)
- Gediz Dogay Us (ORCID: https://orcid.org/0000-0003-0313-8673)
- Ine Lowyck
- Francesco Innocenti (ORCID: https://orcid.org/0000-0002-3717-267X)
- Judith Wellens (ORCID: https://orcid.org/0000-0002-1647-8151)
- Christophe Van Steenkiste (ORCID: https://orcid.org/0000-0001-5167-744X)
- Kitty De Munck
- Marjolijn Uitterhoeve-Prins
- Loes van Bokhoven
- M. Ugur
- Heddy. Van Leeuwen-Wintjens
- Kirsten Stinkens
- Eva Rubens
- Jan Gyselaers
- M.H. Us
- Demi P.A.van Malde
- Toon Meyers
- Anneleen Robaeys
- Leen JM. Heyens
- Roy Remmen
- Jacques Germaux
- Marlies Devos
- Mathieu Struyve
- Sjors Pietermans
- Canio Gilio
- Liesbeth Vernijns
- Katrien Joris
- Michelle Bremers
- Sven Francque
- Ruth Bollen
Institutions
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Antwerp University Hospital (BE)
- Ziekenhuis Oost-Limburg (BE)
- Hasselt University (BE)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1016/j.aohep.2025.102176
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Fonds Wetenschappelijk Onderzoek
- Limburg Sterk Merk
- Universiteit Hasselt
- Vlaamse regering