Hispanic ancestry as a modifier of neuroinflammatory gene expression in single and mixed etiology dementias
These preliminary findings suggest an ancestry- and etiology-specific transcriptional profile in CVD, and point to few genes modified by ancestry in AD and ADCVD. Ongoing experiments aim to determine differential gene expression relative to pathology, and to develop functional genetic models for screening. Overall, we seek to identify Hispanic ancestry- and disease-specific genes among dementia etiologies as an avenue for precision medicine dementia care among an at-risk, underrepresented population.
Authors
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Kevin F. Bieniek (ORCID: https://orcid.org/0000-0003-4922-864X)
- Brittany N. Dugger (ORCID: https://orcid.org/0000-0003-2141-8855)
- Savannah Barannikov
- Mallory Keating
- Elizabeth Ochoa
- Margaret E Flanagan
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- WinnMed (US)
- Institute for Neurodegenerative Disorders (US)
- Mayo Clinic in Florida (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106709
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00