Persistent Homology Classifies Parameter Dependence of Patterns in Turing Systems

This paper illustrates a further application of topological data analysis to the study of self-organising models for chemical and biological systems. In particular, we investigate whether topological summaries can capture the parameter dependence of pattern topology in reaction diffusion systems, by examining the homology of sublevel sets of solutions to Turing reaction diffusion systems for a range of parameters. We demonstrate that a topological clustering algorithm can reveal how pattern topology depends on parameters, using the chlorite-iodide-malonic acid system, and the prototypical Schnakenberg system for illustration. In addition, we discuss the prospective application of such clustering, for instance in refining priors for detailed parameter estimation for self-organising systems.

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Publication Details

Journal
Bulletin of Mathematical Biology
Published
2025-12-24
DOI
https://doi.org/10.1007/s11538-025-01552-9
Primary Topic
Topological and Geometric Data Analysis
Type
article
Field-Weighted Citation Impact
0.00

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article

Persistent Homology Classifies Parameter Dependence of Patterns in Turing Systems

Bulletin of Mathematical Biology
Topological and Geometric Data Analysis
article

Persistent Homology Classifies Parameter Dependence of Patterns in Turing Systems

article en

Abstract

This paper illustrates a further application of topological data analysis to the study of self-organising models for chemical and biological systems. In particular, we investigate whether topological summaries can capture the parameter dependence of pattern topology in reaction diffusion systems, by examining the homology of sublevel sets of solutions to Turing reaction diffusion systems for a range of parameters. We demonstrate that a topological clustering algorithm can reveal how pattern topology depends on parameters, using the chlorite-iodide-malonic acid system, and the prototypical Schnakenberg system for illustration. In addition, we discuss the prospective application of such clustering, for instance in refining priors for detailed parameter estimation for self-organising systems.

Bulletin of Mathematical BiologyVol. 88(1)
University of Oxford (GB), Mathematical Institute of the Slovak Academy of Sciences (SK), Center for Systems Biology Dresden (DE), Max Planck Institute of Molecular Cell Biology and Genetics (DE), University College London (GB), Technische Universität Dresden (DE)
Versus Arthritis, Engineering and Physical Sciences Research Council
Openalex Percentile: Top 28%
Topological and Geometric Data Analysis
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Persistent Homology Classifies Parameter Dependence of Patterns in Turing Systems · Bulletin of Mathematical Biology (2025) | TGRS Research Map | TGRS