Visible-Light Photoredox-Catalyzed Alkylation/1,2-Aryl Migration of Allylic Alcohols with Malonic Esters Leading to δ-Keto Esters
A visible-light photoredox-catalyzed strategy has been developed for the synthesis of δ-keto esters through alkylation/1,2-aryl migration of allylic alcohols with malonic esters. This transformation could be undergone at room temperature in a step- and atom-economic manner by using Eosin Y and air as a metal-free photocatalyst and green oxidant, respectively. Preliminary mechanistic analysis suggested that 1,2-aryl migration proceeded through a radical process.
Authors
- Wei Wu (ORCID: https://orcid.org/0000-0002-7945-9847)
- Yimou Gong (ORCID: https://orcid.org/0009-0006-8628-085X)
- Dong Yi (ORCID: https://orcid.org/0000-0003-2594-0464)
- Zuli Wang (ORCID: https://orcid.org/0009-0003-2695-8743)
- Zi Yang
- Huilan Yue
- Zhuoming Ma
- Huanhuan Cui
Institutions
- Changsha Medical University (CN)
- Nanjing Forestry University (CN)
- Southwest Medical University (CN)
- Qinghai Tibetan Hospital (CN)
- Green Chemistry (PL)
- Zaozhuang University (CN)
- Northwest Institute of Plateau Biology
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1021/acs.joc.5c02904
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00