Investigating the Tau proteoform landscape of human brain using a single‐molecule analysis platform

The single molecule platform has proven effective in quantifying the molecular heterogeneity of Tau proteoforms in human brain tissue. This analysis begins to enhance our understanding of Tau's role in Alzheimer's disease, highlighting its potential for developing more sensitive diagnostic approaches based on proteoform heterogeneity. This study sets the stage for future research on the impact of specific Tau proteoforms on neurodegenerative disease progression and their utility as biomarkers for AD.