Recent advances in Pd-catalysed decarboxylative asymmetric allylic alkylation

This comprehensive review on the Pd-catalysed decarboxylative asymmetric allylic alkylation details the development of this important transformation from its origins to more recent advances. Selected examples of this synthetically mild methodology being applied in natural product synthesis are given. The mechanism is explored in detail, to provide a thorough insight on the current understanding, which is built upon the combination of experimental and computational studies.