Understanding Clinical and Biophysical Differences Between Non‐Cross‐Linked and Cross‐Linked Hyaluronic Acid Dermal Fillers
NCFs and CFs exhibit distinct rheological profiles, with NCFs demonstrating a greater change in their initial rheologic properties when exposed to mechanical stress. This specific biophysical behavior (increase in stiffness and viscosity) predisposes NCFs for dermal structural support with the respective subdermal applications, whereas CFs seem to be more suitable for deep soft tissue injections, offering volumization.
Authors
- Sílvia Fontenete (ORCID: https://orcid.org/0000-0003-1972-6349)
- Michael G. Alfertshofer (ORCID: https://orcid.org/0000-0002-4892-2376)
- Carlos Bravo
- Sebastian Cotofana
Institutions
- Queen Mary University of London (GB)
- Erasmus MC (NL)
- Guangdong Provincial People's Hospital (CN)
- Ludwig-Maximilians-Universität München (DE)
- Vanderbilt University Medical Center (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1111/jocd.70595
- Primary Topic
- Facial Rejuvenation and Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00