Cryo‐EM structures of Fab‐bound CHIP E3 ligase reveal conformational switching and dual roles in regulation of tau accumulation
Structural and functional screening of Fabs that were generated to specifically target 3D epitopes on CHIP revealed potent modes of CHIP functional modulation. Insights from the corresponding CHIP-Fab structures help in better understanding the CHIP-driven tau clearance mechanisms and in describing unique therapeutic target sites on CHIP.
Authors
- Emily J. Connelly (ORCID: https://orcid.org/0000-0003-0732-1627)
- Aparna Unnikrishnan (ORCID: https://orcid.org/0000-0002-6668-8659)
- Dong hee Chung
- Aye C. Thwin (ORCID: https://orcid.org/0000-0002-1423-8189)
- Jason E. Gestwicki (ORCID: https://orcid.org/0000-0002-6125-3154)
- Shweta Devi
- Charles S. Craik (ORCID: https://orcid.org/0000-0001-7704-9185)
- Daniel Southworth
Institutions
- University of California, San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103348
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00