Elucidating the Interaction Dynamics Between a Novel Terpolymer and Aβ42: Unlocking Therapeutic Potential for Alzheimer's Disease
This study highlights the capability of the terpolymer in modulating Aβ42 aggregation dynamics, mitigating toxic oligomer formation and alleviating its neurotoxic effects. These findings present a promising approach for developing polymer-based therapies targeting Alzheimer's disease, offering a novel pathway to combat neurodegeneration. References Okumura, H., J Phys Chem B 2023, 127 (51), 10931-10940. Park E, et al. Advanced Science. 2023, 10(12):2207238. Li, L.Y.; Park, E. et al. Nanotoxicology 2024, 1-20. Li, L.Y.; Park, E. et al. Nanotoxicology 2024, 1-20.
Authors
- Lily Yi Li (ORCID: https://orcid.org/0000-0002-1666-9556)
- Jeffrey T. Henderson (ORCID: https://orcid.org/0000-0001-7636-2604)
- Sako Mirzaie (ORCID: https://orcid.org/0000-0003-4080-9210)
- Xiao Yu Wu (ORCID: https://orcid.org/0000-0002-5333-8115)
- P. E. Fraser
- Chunsheng He
Institutions
- University of Toronto (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103257
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00