The role of microbiota‐derived exosomes in Alzheimer's disease and dementia progression and management

This study underscores the importance of microbiota-derived exosomes in understanding Alzheimer's disease and dementia progression. The findings suggest the gut-brain axis, mediated in part by these exosomes, represents a promising avenue for future research and effective therapeutic interventions as targeting these exosomes could offer novel therapeutic strategies for managing neurodegenerative diseases. However, further studies are needed to fully elucidate the mechanisms involved and translate these findings into clinical applications. This work contributes to the growing body of evidence supporting the microbiota-gut-brain axis as a critical area of investigation for neurodegenerative disease research.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_102839
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

The role of microbiota‐derived exosomes in Alzheimer's disease and dementia progression and management

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The role of microbiota‐derived exosomes in Alzheimer's disease and dementia progression and management

Chukwuebuka Asogwa, Ajibola Moshood, Fatola Ayomide, Henry Demian Oyoyo, Jonas Ibekwe, Olatunji Zion, Ogbeide Marvellous Aghahowa, Olarenwaju Timileyin
article en

Abstract

This study underscores the importance of microbiota-derived exosomes in understanding Alzheimer's disease and dementia progression. The findings suggest the gut-brain axis, mediated in part by these exosomes, represents a promising avenue for future research and effective therapeutic interventions as targeting these exosomes could offer novel therapeutic strategies for managing neurodegenerative diseases. However, further studies are needed to fully elucidate the mechanisms involved and translate these findings into clinical applications. This work contributes to the growing body of evidence supporting the microbiota-gut-brain axis as a critical area of investigation for neurodegenerative disease research.

Alzheimer s & DementiaVol. 21(S1)
University of Ibadan (NG), Forestry Research Institute of Nigeria (NG), University College Hospital, Ibadan (NG), University of Benin Teaching Hospital (NG), University of Benin (NG)
Openalex Percentile: Top 36%
Gut microbiota and health
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The role of microbiota‐derived exosomes in Alzheimer's disease and dementia progression and management — Chukwuebuka Asogwa, Ajibola Moshood, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS