Sex-dependent immune activation shapes disease progression in a model of Parkinson’s disease
Together, these findings reveal distinct immune signaling in male and female 3KL mice and identify coordinated changes in T cell and microglial responses that may contribute to sex differences in PD vulnerability and progression. This work underscores the importance of incorporating sex as a biological variable in neurodegeneration research and provides mechanistic insight into immune-mediated modulation of synucleinopathy.
Authors
- Toby B. Lanser (ORCID: https://orcid.org/0000-0002-2250-6075)
- Laura M. Cox (ORCID: https://orcid.org/0000-0002-9564-9894)
- Leah C. Beauchamp (ORCID: https://orcid.org/0000-0002-4896-279X)
- Lily A. Palumbo
- Mariam Baig
Institutions
- Brigham and Women's Hospital (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s13293-025-00809-1
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39