Lurasidone and Fluvoxamine Combination in Eating Disorders with Comorbid Obsessive–Compulsive Disorder: Preliminary Evidence from an Observational Study

Within the constraints of this small, all-female inpatient cohort, the findings illustrate directional, time-related changes compatible with global rehabilitation effects rather than drug-specific efficacy. The study demonstrates the feasibility-and methodological challenges-of applying Bayesian longitudinal modeling to incomplete clinical datasets. Future randomized or adaptive trials incorporating objective endpoints and data-quality pipelines are warranted to test whether serotonergic-dopaminergic-σ-1 synergy provides genuine clinical benefit in the AN-OCD spectrum.

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Publication Details

Journal
Medical Sciences
Published
2025-12-23
DOI
https://doi.org/10.3390/medsci14010008
Primary Topic
Obsessive-Compulsive Spectrum Disorders
Type
article
Field-Weighted Citation Impact
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article

Lurasidone and Fluvoxamine Combination in Eating Disorders with Comorbid Obsessive–Compulsive Disorder: Preliminary Evidence from an Observational Study

Francesco Monaco, Ernesta Panarello, Stefania Landi, Luca Steardo et al.
Medical Sciences
Obsessive-Compulsive Spectrum Disorders
article

Lurasidone and Fluvoxamine Combination in Eating Disorders with Comorbid Obsessive–Compulsive Disorder: Preliminary Evidence from an Observational Study

Francesco Monaco, Ernesta Panarello, Stefania Landi, Luca Steardo, Annarita Vignapiano, Giuseppe Scarano, Giovanna Celia, Giulio Corrivetti, Mauro Cozzolino
article en

Abstract

Within the constraints of this small, all-female inpatient cohort, the findings illustrate directional, time-related changes compatible with global rehabilitation effects rather than drug-specific efficacy. The study demonstrates the feasibility-and methodological challenges-of applying Bayesian longitudinal modeling to incomplete clinical datasets. Future randomized or adaptive trials incorporating objective endpoints and data-quality pipelines are warranted to test whether serotonergic-dopaminergic-σ-1 synergy provides genuine clinical benefit in the AN-OCD spectrum.

Medical SciencesVol. 14(1)
University of Salerno (IT), Magna Graecia University (IT), European Biomedical Research Institute of Salerno (IT), Pegaso University (IT)
Good health and well-being
Openalex Percentile: Top 28%
Obsessive-Compulsive Spectrum Disorders
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Lurasidone and Fluvoxamine Combination in Eating Disorders with Comorbid Obsessive–Compulsive Disorder: Preliminary Evidence from an Observational Study — Francesco Monaco, Ernesta Panarello, et al. · Medical Sciences (2025) | TGRS Research Map | TGRS