Lurasidone and Fluvoxamine Combination in Eating Disorders with Comorbid Obsessive–Compulsive Disorder: Preliminary Evidence from an Observational Study
Within the constraints of this small, all-female inpatient cohort, the findings illustrate directional, time-related changes compatible with global rehabilitation effects rather than drug-specific efficacy. The study demonstrates the feasibility-and methodological challenges-of applying Bayesian longitudinal modeling to incomplete clinical datasets. Future randomized or adaptive trials incorporating objective endpoints and data-quality pipelines are warranted to test whether serotonergic-dopaminergic-σ-1 synergy provides genuine clinical benefit in the AN-OCD spectrum.
Authors
- Francesco Monaco (ORCID: https://orcid.org/0000-0002-5617-7943)
- Ernesta Panarello (ORCID: https://orcid.org/0009-0002-6270-6490)
- Stefania Landi (ORCID: https://orcid.org/0009-0000-7373-2665)
- Luca Steardo
- Annarita Vignapiano (ORCID: https://orcid.org/0009-0004-8301-3401)
- Giuseppe Scarano
- Giovanna Celia
- Giulio Corrivetti
- Mauro Cozzolino
Institutions
- University of Salerno (IT)
- Magna Graecia University (IT)
- European Biomedical Research Institute of Salerno (IT)
- Pegaso University (IT)
Publication Details
- Journal
- Medical Sciences
- Published
- 2025-12-23
- DOI
- https://doi.org/10.3390/medsci14010008
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00