Investigation of the roles of microglia and astrocytes in cerebral amyloid angiopathy across diverse murine strains

Given the differential susceptibility of B6, WSB, and BXW genetic backgrounds to CAA development and the potential role of microglia and astrocytes in modulating susceptibility to CAA. It is possible that B6, WSB and BXW.APP/PS1's unique cell response influences amyloid deposition in the vasculature, leading to CAA. Understanding the role of microglia and astrocytes in AD-relevant pathologies will help further the field in the target microglial activity and proliferation as it shows an inverse relationship with CAA expression across strains.