Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis

More than half of the ATTR-CA patients have AF, which was associated with wild-type amyloid transthyretin, greater Columbia stage, and increased LAVI. About half of the ATTR-CA individuals developed AF after 2 years, which was predicted by the Columbia score, but not the CHARGE-AF score. ATTRv and tafamidis were protective against incident AF.

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Publication Details

Journal
JACC Advances
Published
2025-12-24
DOI
https://doi.org/10.1016/j.jacadv.2025.102470
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
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article

Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis

Jeffeny De Los Santos, Margaret Cuomo, Elaine Y. Wan, José Dizon et al.
JACC Advances
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis

Jeffeny De Los Santos, Margaret Cuomo, Elaine Y. Wan, José Dizon, Yevgeniy Brailovsky, Alfonsina Mirabal, Nicholas Chan, Stephen Helmke, Samantha Guadalupe, Hirad Yarmohammadi, Massiel Jimenez, Dia Smiley, Angelo Biviano, Ariel Y. Weinsaft, Sergio Teruya, Mathew S. Maurer
article en

Abstract

More than half of the ATTR-CA patients have AF, which was associated with wild-type amyloid transthyretin, greater Columbia stage, and increased LAVI. About half of the ATTR-CA individuals developed AF after 2 years, which was predicted by the Columbia score, but not the CHARGE-AF score. ATTRv and tafamidis were protective against incident AF.

JACC AdvancesVol. 5(2)
NewYork–Presbyterian Hospital (US), Columbia University Irving Medical Center (US), New York Hospital Queens (US), Columbia University (US)
Openalex Percentile: Top 36%
Amyloidosis: Diagnosis, Treatment, Outcomes
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Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis — Jeffeny De Los Santos, Margaret Cuomo, et al. · JACC Advances (2025) | TGRS Research Map | TGRS