Pathogenic or Likely Pathogenic <scp> <i>GRN</i> </scp> Variants Are Found in 0.1% of Parkinson's Disease Patients
FTD-GRN may be indistinguishable from PD. Therefore, comprehensive genetic testing, including GRN analysis, is recommended for patients with clinically diagnosed parkinsonism/PD to guide disease management and prognosis. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Jörg Rennecke
- Vítor Tumas (ORCID: https://orcid.org/0000-0003-2402-2709)
- Tanya Gurevich (ORCID: https://orcid.org/0000-0003-2092-9848)
- Patrícia de Carvalho Aguiar (ORCID: https://orcid.org/0000-0003-2957-9573)
- Ilona Csóti (ORCID: https://orcid.org/0000-0002-3867-6837)
- Anna De Rosa (ORCID: https://orcid.org/0000-0002-5618-2478)
- Erich Talamoni Fonoff (ORCID: https://orcid.org/0000-0001-7831-9941)
- Thomas Musacchio (ORCID: https://orcid.org/0000-0001-8416-4106)
- Esther Sammler (ORCID: https://orcid.org/0000-0003-3218-7116)
- Anna Negrotti
- Mitra Afshari (ORCID: https://orcid.org/0000-0003-4803-953X)
- Katrin Reetz
- Sumanth Mannepalli
- Deepa Saravanakumar
- Filipa Curado (ORCID: https://orcid.org/0000-0003-3311-0081)
- Doreen Gruber (ORCID: https://orcid.org/0009-0009-4335-4718)
- Omid Paknia (ORCID: https://orcid.org/0000-0003-1173-5363)
- Peter Bauer
- Franco Valzania
- J Kulisevsky
- Wim Vandenberghe (ORCID: https://orcid.org/0000-0002-9758-5062)
- Nicola Pavese
- Sharon Hassin‐Baer
- Björn‐Hergen Laabs
- Juan Carlos Gomez‐Esteban
- Jefri J. Paul
- Christian A. Ganoza (ORCID: https://orcid.org/0000-0002-5891-5372)
- Christine Klein
- Ruslan Al‐Ali
- Christian Beetz
- Ana Westenberger
- Emir Zonic
Institutions
- University of Parma (IT)
- Tel Aviv University (IL)
- University of Dundee (GB)
- Universidade de São Paulo (BR)
- Tel Aviv Sourasky Medical Center (IL)
- Sheba Medical Center (IL)
- Hospital Israelita Albert Einstein (BR)
- Hospital de Sant Pau (ES)
- University of Illinois Chicago (US)
- University of Chicago (US)
- BioCruces Health research Institute (ES)
- Rostocker Zentrum zur Erforschung des Demografischen Wandels (DE)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- MRC Protein Phosphorylation and Ubiquitylation Unit (GB)
- Schulthess-Klinik (CH)
- Universitätsmedizin Göttingen (DE)
- Federico II University Hospital (IT)
- Universitätsklinikum Würzburg (DE)
- Neurologisches Fachkrankenhaus für Bewegungsstörungen/Parkinson (DE)
- NIHR Newcastle Biomedical Research Centre (GB)
- Jülich Aachen Research Alliance (DE)
- Ospedale di Parma (IT)
- Centogene (Germany) (DE)
- Hospital Sírio-Libanês (BR)
- Newcastle Hospitals - Campus for Ageing and Vitality (GB)
- Newcastle University (GB)
- RWTH Aachen University (DE)
- Medical Research Council (GB)
- University of Lübeck (DE)
- KU Leuven (BE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1002/mds.70161
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Denali Therapeutics