Transcriptomic profiling of glutamatergic gliotransmission‐specialized astrocytes in Alzheimer's disease mouse models

Our results show that the glutamatergic astrocyte signature varies in AD mouse models, with significant differences in their enrichment and gene expression profiles. The APP/PS1 and hAβKI models showed substantial enrichment of this astrocyte subtype, whereas the 5xFAD model exhibited minimal representation. The significant downregulation of genes related to vesicle trafficking suggests potential impairments in glutamatergic astrocyte function. Our findings highlight the role of a specific astrocyte subtype in AD pathogenesis. Further single-cell analysis will provide more information at the cellular level.