Leveraging menopause to uncover novel insights into Alzheimer's disease pathophysiology

Leveraging female-specific biology can uncover new insights into tau biology. In postmenopausal women, age of menopause associated with a range of biological factors relevant for brain aging, particularly immune, synaptic, and tau biology. AGRN, a secreted extracellular matrix heparin-sulfate glycoprotein, most consistently associated with menopause-related tau biomarkers and may be a candidate to explain female-specific vulnerability to tau.