Fecal levels of short‐chain fatty acids and prominent bacterial taxa involved in their production are inversely associated with amyloid‐positive status
Relative abundances of MAGs encoding enzymes for propionate and butyrate production were reduced in amyloid-positive participants in a cognitively unimpaired human cohort enriched for AD risk. These results, combined with the extensive literature in preclinical AD mouse models, suggest that SCFA may play a causal role in AD progression.
Authors
- Margo B. Heston (ORCID: https://orcid.org/0000-0002-0980-2275)
- Nancy J. Davenport‐Sis (ORCID: https://orcid.org/0000-0001-6150-3590)
- Tyler K. Ulland
- Federico E. Rey (ORCID: https://orcid.org/0000-0002-0239-7780)
- Sushma Shankar
- Aiden Cook
- Jea Woo Kang (ORCID: https://orcid.org/0000-0003-1202-4432)
- Qijun Zhang (ORCID: https://orcid.org/0000-0002-1003-7355)
- Kaj Blennow
- Michelle Ji Yeon Yoo (ORCID: https://orcid.org/0000-0002-3758-5298)
- Jessamine F. Kuehn (ORCID: https://orcid.org/0000-0002-2719-2474)
- Justus Zemberi
- Éric Zhang (ORCID: https://orcid.org/0000-0002-9271-9156)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Sandra Harding
- E Schiffmann
- Robert L. Kerby (ORCID: https://orcid.org/0000-0003-1565-6486)
- Alissa Mickol
- Eleanor Clements
- Joseph Harpt
- Barbara B. Bendlin
- Hana Chow
- Henrik Zetterberg
- Cynthia M. Carlsson
- Joseph L. Wheeler
- Sterling C. Johnson
- Aaliyah Mushtaque
Institutions
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Wisconsin Division of Public Health (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098071
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00