Modulation of hippocampal astrocytes in aged rats through insulin‐growth factor 1 gene therapy
This study presents an innovative therapeutic strategy targeting hippocampal astrocytes in aged rats using a genetic vector to overexpress IGF1. The treatment successfully modulated IGF1 expression in these cells, resulting in partial improvements in behaviour and memory function, highlighting its potential for age-related cognitive decline.
Authors
- Paula C. Reggiani (ORCID: https://orcid.org/0000-0003-3784-3864)
- Facundo Peralta (ORCID: https://orcid.org/0009-0004-8470-460X)
- Ana Abril Vidal Escobedo
- Joaquín Pardo
- Julia Emilia Alejandra Diaz Baliero
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de La Plata (AR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104067
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00