Impact of Prior History of Traumatic Stress on Autonomic and Multi-System Symptoms Following COVID-19 Infection
Prior history of traumatic stress has a positive and interactive effect on symptoms of autonomic dysregulation following COVID-19 infection, independent of PTSD symptoms. This suggests that exposure to traumatic stress may affect the response to future stressors, including physiologic stressors such as COVID-19 infection, through persistent changes in stress-threat response systems. This relationship may provide a physiologic explanation for prior observations that baseline anxiety prior to COVID-19 infection is associated with increased likelihood of PASC.
Authors
- John C. Oakley
- Katharine J. Liang (ORCID: https://orcid.org/0000-0002-0520-0613)
- Marlene Tai
- Abigail G. Schindler (ORCID: https://orcid.org/0000-0002-7039-1348)
- Kathleen F. Pagulayan (ORCID: https://orcid.org/0000-0002-8010-1631)
- Christine S. Cheah
- Aaron F. Rosser (ORCID: https://orcid.org/0000-0001-5086-389X)
- Rebecca C. Hendrickson (ORCID: https://orcid.org/0000-0003-2377-823X)
- Catherine McCall (ORCID: https://orcid.org/0000-0002-3697-1496)
- Kimberly Hart
Institutions
- University of Washington (US)
- California Pacific Medical Center (US)
- VA Puget Sound Health Care System (US)
- Mental Illness Research, Education and Clinical Centers (US)
Publication Details
- Journal
- Chronic Stress
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1177/24705470251407210
- Citations
- 1
- Primary Topic
- COVID-19 and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 2.31