The parity paradox: Differential effects on functional connectivity depending on APOEε4 genotype in middle age
By revealing distinct patterns of network organization and regional importance, this study provides insight into the neural networks underlying cognition altered by primiparity and hAPOEε4 in middle-aged female rats. These findings also demonstrate that considering within-sex factors is crucial to unraveling the dynamic effects of AD risk on brain health outcomes.
Authors
- Bonnie H. Lee (ORCID: https://orcid.org/0000-0002-7661-9243)
- Jonathan R. Epp (ORCID: https://orcid.org/0000-0002-7968-8973)
- Liisa A.M. Galea (ORCID: https://orcid.org/0000-0003-2874-9972)
- Sandra Mitchell
- Stephanie E. Lieblich
- Andrew J McGovern
- Jie Yin
Institutions
- Centre for Addiction and Mental Health (CA)
- University of British Columbia (CA)
- University of Calgary (CA)
- University of Toronto (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100368
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00