Transitional Type Circulating Tumor Cells Predict Systemic Recurrence and Support Risk Stratification for Chemotherapy After Resection of Pancreatic Ductal Adenocarcinoma
Preoperatively, higher trCTC counts are associated with increased risk of systemic recurrence, while postoperative presence reflects minimal residual disease. Integrating trCTC assessment alongside currently used biomarkers into the clinical pathway for patients with PDAC could enhance risk stratification and support more personalized treatment decisions.
Authors
- Greg D. Sacks (ORCID: https://orcid.org/0000-0003-1205-6477)
- J. He
- Katherine A. Morgan (ORCID: https://orcid.org/0000-0002-2874-8737)
- Alessio Marchetti
- Ingmar F. Rompen (ORCID: https://orcid.org/0000-0002-0257-1654)
- Awais Javed (ORCID: https://orcid.org/0000-0002-2686-8006)
- Elisabetta Sereni
- Josef Habib
- Christopher L. Wolfgang
- D. Brock Hewitt
Institutions
- Johns Hopkins University (US)
- Heidelberg University (DE)
- Johns Hopkins Medicine (US)
- University Hospital Heidelberg (DE)
- NYU Langone Health (US)
- New York University Langone Orthopedic Hospital (US)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1097/sla.0000000000006998
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00