Cross‐Species Insights into Cognition: Translating Findings from Mice to Humans at‐risk for Alzheimer's Disease

This talk will explore the integration of touchscreen-based cognitive testing into both human and mouse studies and its role in elucidating the mechanisms of AD risk. I will discuss how PREVENT-AD human and mouse touchscreen CPT data can shed light on the interaction of ApoE genotype, age, and sex in early cognitive dysfunction. Additionally, I will explore whether touchscreen tests of cognition differ from standard neuropsychological tests in their sensitivity to early AD-related decline. Finally, I will outline plans to expand the use of touchscreen tests within PREVENT-AD and other large-scale consortia. By linking genetic risk, cognitive performance, and neurobiological markers, this cross-species approach will advance our understanding of AD's earliest manifestations and support the development of targeted interventions.