Defining a multifaceted role of <i>DNAJC5/</i> CSPα in cell autonomous Alzheimer's disease proteostasis
Our study on mutant CSPα reveals cell type-specific aggregation phenotypes and altered proteostatic pathways, which we believe will have broader implications on AD-related proteinopathies. Ongoing multi-omics analysis will further determine cell-type-specific CSPα-associated neurodegenerative pathways, and future functional assays will further elucidate how CSPα regulates AD proteostasis.
Authors
- Matthew J Rosene (ORCID: https://orcid.org/0000-0002-4243-3678)
- Bruno A. Benítez (ORCID: https://orcid.org/0000-0002-2699-3878)
- Adeeb Uddin Ahmad
- Skarleth Cardenas Romero
- Mei‐Yu Lai
- Abraham Lopez
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Beth Israel Deaconess Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100325
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00