Prevention of human Abeta induced synaptic deficits by hAPOE4
hAb induces robust LTP deficits that are prevent by hAPOE4, from 4 months of age. These results are in agreement with the excessive synaptic loss observed in the hAb-KI<sup>loxP</sup> mice, which is also rescued by the addition of the hAPOE4 variant. Further studies are needed to fully understand the differences between murine and human APOE4 and how this could be modulating the effects of hAb on synaptic integrity and function.
Authors
- Marcelo A. Wood (ORCID: https://orcid.org/0000-0003-2029-4176)
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Enikö A. Kramár (ORCID: https://orcid.org/0009-0003-2279-7743)
- Yegang Lü (ORCID: https://orcid.org/0000-0003-3845-5038)
- Shimako Kawauchi (ORCID: https://orcid.org/0000-0002-8577-4763)
- Frank La Ferla
- Grant R. MacGregor (ORCID: https://orcid.org/0000-0001-7598-9501)
- Ian F. Smith (ORCID: https://orcid.org/0000-0001-9910-195X)
- Angela Gomez‐Arboledas
- Kim N. Green
- Celia Da Cunha
- Giedre Milinkeviciute
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106907
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00