Mapping the prevalence of molecular markers of <i>Plasmodium falciparum</i> artemisinin partial resistance in Africa: a spatial-temporal modelling study
The rapid and multicentric expansion of <i>k13</i> ART-R mutations in East Africa threatens ACT efficacy, especially where ART-R <i>k13</i> and partner drug markers co-occur, mirroring early patterns observed before ACT failure in Southeast Asia. This study provides an updated <i>k13</i> ART-R mutation database and high-resolution resistance maps with uncertainty quantification, demonstrating a crucial need to prioritize targeted molecular surveillance across greater East Africa to safeguard ACT efficacy.
Authors
- Karamoko Niaré (ORCID: https://orcid.org/0000-0002-7406-9508)
- Neeva Wernsman Young (ORCID: https://orcid.org/0000-0002-0131-7670)
- Alfred Simkin (ORCID: https://orcid.org/0000-0001-9408-0053)
- J. Daniel Bailey (ORCID: https://orcid.org/0000-0002-6401-0692)
- Melissa D. Conrad (ORCID: https://orcid.org/0000-0002-9984-8030)
- Sean V. Connelly (ORCID: https://orcid.org/0000-0002-7330-7340)
- Oliver John Watson (ORCID: https://orcid.org/0000-0003-2374-0741)
- Gina Cuomo-Dannenburg (ORCID: https://orcid.org/0000-0001-6821-0352)
- Jonathan B. Parr (ORCID: https://orcid.org/0000-0002-4465-9830)
- Deus S. Ishengoma (ORCID: https://orcid.org/0000-0003-2040-3416)
- Kelly Carey-Ewend (ORCID: https://orcid.org/0000-0002-3200-1644)
- Jonathan J. Juliano (ORCID: https://orcid.org/0000-0002-0591-0850)
- George A. Tollefson (ORCID: https://orcid.org/0000-0002-7924-7844)
- Robert Verity (ORCID: https://orcid.org/0000-0002-3902-8567)
- Abebe A. Fola (ORCID: https://orcid.org/0000-0001-5392-2859)
- Dr Lucy Okell
- Jacob Marglous (ORCID: https://orcid.org/0000-0002-3592-1382)
- Ronald Futila Kyong-Shin
- Isabela Gerdes Gyuricza
- Shazia Ruybal-Pesántez
- Cécile P. G. Meier-Scherling
- Zachary R. Popkin-Hall
- Ayalew Jejaw Zeleke
Institutions
- University of North Carolina at Chapel Hill (US)
- Ifakara Health Institute (TZ)
- University of North Carolina Health Care (US)
- Johns Hopkins University (US)
- Western Connecticut State University (US)
- Rega Institute for Medical Research (BE)
- Brown University (US)
- National Institute of Biomedical Research (CD)
- National Institute for Medical Research (TZ)
- Imperial College London (GB)
- Universidad San Francisco de Quito (EC)
- University of Gondar (ET)
- KU Leuven (BE)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-23
- DOI
- https://doi.org/10.64898/2025.12.22.25342873
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.88