Assessing the Relationship of APOE SNPs and Dementia in Native Hawaiians and Pacific Islanders

Neither the ε2 nor the ε4 APOE alleles predict MCI in NHPIs. Although our cohort is relatively small, we have sufficient power to detect effect sizes comparable to ε2 and ε4 effects in other populations. Research in other Indigenous populations has also failed to detect a significant correlation between APOE and dementia.