A label-free fluorescent probe for deferiprone quantification in exhaled breath condensate utilizing UiO-66 MOF/ferric ions system
This study developed a simple and label-free fluorescent probe for deferiprone quantification in exhaled breath condensate (EBC) samples. For that, UiO-66, synthesized in a one-step process with the solvothermal method, along with ferric ions, provided a selective system for deferiprone detection. Deferiprone formed a complex with ferric ions, and the resulting complex quenched the fluorescence intensity of UiO-66 through an inner filter effect process. The probe demonstrated good sensitivity, with a detection limit of 0.005 mg.L<sup>- 1</sup> and a linear range of 0.016-1.0 mg.L<sup>- 1</sup>, and performed reliably in the analysis of deferiprone in EBC samples of the patients.
Authors
- Zahra Karimzadeh (ORCID: https://orcid.org/0000-0001-8501-7124)
- Elaheh Rahimpour (ORCID: https://orcid.org/0000-0002-4037-9436)
- Abolghasem Jouyban
- Maryam Khoubnasabjafari
- Vahid Jouyban-Gharamaleki
- Nima Sheikh Abdollahzadeh Mamaghani
Institutions
- Tabriz University of Medical Sciences (IR)
- University of Tabriz (IR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1038/s41598-025-33395-8
- Citations
- 1
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.11