Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women

In women with preclinical AD (Aβ+/CU), late motherhood was associated with a more deleterious effect on the change of memory performance later in life. Findings suggest a complex interplay between pregnancy history and AD pathology in women. The lack of findings in men and influence of socioeconomic factors suggest that pregnancy-related biological or hormonal factors may be driving the relationship in women.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_101674
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
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article

Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women

Erin E. Sundermann, Anna Brugulat‐Serrat, Ana Fernández‐Arcos, Kaj Blennow et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women

Erin E. Sundermann, Anna Brugulat‐Serrat, Ana Fernández‐Arcos, Kaj Blennow, David López‐Martos, for the ALFA study, Clara Gallay, Gonzalo Sánchez‐Benavides, Oriol Grau‐Rivera, Marc Suárez‐Calvet, Henrik Zetterberg, Juan Domingo Gispert
article en

Abstract

In women with preclinical AD (Aβ+/CU), late motherhood was associated with a more deleterious effect on the change of memory performance later in life. Findings suggest a complex interplay between pregnancy history and AD pathology in women. The lack of findings in men and influence of socioeconomic factors suggest that pregnancy-related biological or hormonal factors may be driving the relationship in women.

Alzheimer s & DementiaVol. 21(S2)
Universitat Pompeu Fabra (ES), Sahlgrenska University Hospital (SE), University of California San Diego (US), Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES), Pasqual Maragall Foundation (ES), UK Dementia Research Institute (GB), Barcelonaβeta Brain Research Center (ES), Hospital Del Mar (ES), Municipal Institute for Medical Research (ES), Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES), National Hospital for Neurology and Neurosurgery (GB), Hospital del Mar Research Institute (ES), University College London (GB), University of Gothenburg (SE)
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Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women — Erin E. Sundermann, Anna Brugulat‐Serrat, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS