The Underlying Pathophysiology of Resilience to Alzheimer's Disease Pathology: Preliminary Results of a CSF Proteomics Study

Resilience to AD is associated with unique protein expression profiles and underlying biological pathways, that vary depending on tau pathology status. Resilience in A+T- individuals is linked to pathways involved in nervous system development, ion response, and amyloid fibril formation, whereas resilience in A+T+ individuals is associated with oxidative stress regulation and synaptic processes. The distinct protein expression patterns observed suggest that different biological mechanisms may contribute to cognitive resilience, and these mechanisms could change as tau pathology progresses.